ABSTRACT
Background: GastroEsophageal Reflux Disease [GERD] is the most common gastrointestinal disorders, which may be caused or aggravated by occupational stress. In this study we aimed to investigate the prevalence of GERD in nurses working in hospitals of a province in Iran and assessing its relationship with their occupational stress
Materials and Methods: The study was a cross-sectional and correlational one. The study population included all nurses working in public hospitals of a province in Iran in 2016. The stratified random sampling was used. The data were collected using Nursing Stress Scale [NSS] and Gastroesophageal Reflux Disease Questionnaire. The SPSS software version 22 and independent t, Chi-square, and Mann-Whitney tests were used for data analysis
Results: The prevalence of GERD and severe levels of occupational stress among nurses were 26.8%, and 25.9%, respectively. Statistical analyses showed no significant correlation between occupational stress and the risk of GERD, but a significant relation was found between the sex of the nurses and their occupational stress and between their type of employment and the risks of GERD
Conclusion: The prevalence of GERD among nurses had no significant difference with that in the general community. Although nursing is considered as a stressful job, it seems that nurses adapt themselves with the working conditions after a while and experience stress levels similar to other people in the community
ABSTRACT
Aim: This study was aimed to evaluating the efficacy of levofloxacin based sequential therapy vs clarithromycin based sequential therapy in h.pylori [HP] eradication
Background: Several therapeutic regimen were investigated to treat HP infection. Sequential therapy is an alternative to classic triple therapy
Methods: In this randomized clinical trial, 200 HP infected patients randomly divided into two therapeutic groups .1-Levofloxacin based sequential regimen [group A]; omeprazole and amoxicillin for 7days followed by omeprazole, amoxicillin and levofloxacin for 7days. 2-clarithromycin based sequential regimen [group B]: omeprazole and amoxicillin for 7days followed by omeprazole, amoxicillin and clarithromycin for 7days. HP eradication was evaluated with urea breath test with carbon 13 [UBT] 6 weeks after the end of treatment
Results: Per protocol eradication rates of group A and B were 87.6% and 76% respectively. By intention to treat analysis, eradication rate of group A and B groups were 85.1% and 73% respectively. Levofloxacin based sequential regimen was more effective than clarithromycin based sequential regimen [Pv=0.028]. Adverse events were seen in 19.6% and 15.6% in group A and B respectively. Drug compliance was 97% in group A and 96% in group B. There was no significant difference between two groups in term of adverse events [p=0.470] and compliance [p=0.651]
Conclusion: Levofluxacin based sequential therapy was more effective than Clarithromycin based sequential therapy in HP eradication. The suggested Levofluxacin based sequential therapy could be an alternative therapy in area with high clarithromycin resistance. Further studies are needed to confirm these findings
ABSTRACT
Background: many patients with irritable bowel syndrome [IBS] may have undiagnosed celiac disease [CD]. Diagnosis of CD is important because early diagnosis can prevent serious complications. The purpose of this study was to investigate the demographic features and prevalence of CD in patients with IBS in Khoram Abad, Lorestan
Materials and Methods: this descriptive cross-sectional study was conducted on 369 patients with IBS who were diagnosed based on Rome III criteria and attended to gastrointestinal clinic of Shohada-y-Ashayer Hospital in KhorramAbad from June 2015 until March 2016. 31 patients did not accept to participate so were excluded from the study. Serological tests were performed and seropositive cases were underwent upper gastrointestinal endoscopy and duodenal biopsy. Data were analyzed using descriptive statistics, t test and Chi-square test through SPSS software version 22
Results: the mean age of the patients with CD was 31+/-12 years and most of them [72.7%] were women. Most of CDs were diarrheal dominant IBS [77.3%]. Among 338 patients who completed the study, 25 patients [7.4%] were seropositive, and CD was confirmed in 22 of them [6.5%] according to the Marsh classification. Marsh I was reported in seven cases, Marsh II in four, and Marsh III in 11 cases
Conclusion: considering the high prevalence of CD [6.5%] in patients with IBS, the overlap of the symptoms, as well as the importance of timely diagnosis of CD, it is suggested to screen CD in patients with IBS